TXA

TXA, or Tranexamic Acid, is an antifibrinolytic agent.

It prevents the breakdown of fibrin, stopping fibrinolysis.

TXA is given through an IV:

• 1 g over 10 minutes (slow push)
• Then 1 g over 8 hours via infusion

TXA should be given within 3 hours of injury for best effect.

Contraindications include, but are not limited to:

• Hypersensitivity to TXA
• Active intravascular clotting
• DVT (deep vein thrombosis)
• PE (pulmonary embolism)
• Stroke
• Heart attack
• Subarachnoid haemorrhage

Use caution in renal impairment.

Points to remember:

Always attempt bleeding control first using:

• Gauze
• Wound packing
• Direct pressure
• Tourniquets

TXA is not a replacement, only an addition to bleeding control.